Zhigang He - IDDRC

Zhigang He, PhD, BM

Research Associate, Boston Children's Hospital; Professor of Neurology and Ophthalmology, Harvard Medical School.

Research Focus

Axon regeneration and function recovery after brain and spinal cord injury.

Brief Research Description

Zhigang He lab's research is interested in developing new function restoration strategies after CNS. Their research has been focusing on the following questions: First, why injured axons cannot regenerate in adult mammalian CNS? Second, in the case of incomplete injury, how to reactivate anatomically incomplete yet functionally dormant connections. Third, in order to design tailored neural repair strategies after spinal cord injury, they are interested in cracking the code of the control of the spinal cord function by the brain. Together, they expect that answering these questions will establish important principles for exploiting regenerative medicine to treat CNS injury and other neurological diseases.

Key Publications (PMCIDs)

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z.
Neuron 2016;92(6):1294-307. PMCID: PMC5189716

Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills.
Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z.
Cell 2017;171(2):440-55 e14. PMCID: PMC5679421

Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.
Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z.
Neuron 2017;94(6):1112-20 e4. PMCID: PMC5519288

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