BCH Logo
BCH Logo
Tang lab

Xin Tang, PhD

Assistant Professor, Harvard Medical School

Research Focus
Understanding brain function and dysfunction from model to mechanism to medicine
Brief Research Description
Our lab seeks to understand the molecular and cellular basis of human brain disorders in order to ultimately develop mechanism-guided therapeutics that relieve disease symptoms. With a research focus on neurodevelopmental disorders, epilepsy, and brain cancer, we create physiologically-relevant models to elucidate disease mechanisms and develop drug and gene discovery platforms to screen for potential therapeutics that can regulate the expression levels of disease risk genes. In order to develop novel precision medicine, we employ a multidisciplinary approach that leverages technologies spanning genome engineering, human stem cell differentiation, organoid culture, single cell-omics, bioinformatics, biochemistry, electrophysiology, and high-throughput gene/drug screening.
Key Publications (PMCIDs)

The role of GABAergic signalling in neurodevelopmental disorders, Nature Reviews Neuroscience
Tang, X., Sur, M., Jaenisch, R.
Nature Reviews Neuroscience, 2021 May;22(5); PMID: 33772226

Pharmacological Enhancement of KCC2 Gene Expression Exerts Therapeutic Benefits on Human Rett Syndrome neurons and Mecp2 mutant mice
Tang, X., Drotar, J., Li, K., Clairmont, CD., Brumm, AS., Wu, H., Liu, XS., Wang, J., Gray, NS., Sur, M., Jaenisch, R.
Science Translational Medicine 2019, PMCID: PMC8140401

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome
Tang X., Kim, J., Zhou, L., Wengert, E., Zhang, L., Wu, Z., Carromeu, C., Muotri, AR., Marchetto, MC., Gage, FH., Chen, G.
Proceedings of the National Academy of Sciences, 2016. PMCID: PMC4725523

Neuronal Chloride Transporters in Health and Disease
Tang, X. (chief editor)
Academic Press, 2020, paperback ISBN: 9780128153185, eBook ISBN: 9780128153192

Genome Editing: Applications for Disease Modeling and Cell Therapy
Tang, X.
Wiley publishing company, 2019

< BACK TO DIRECTORY