Xi He - IDDRC

Xi He, PhD

Research Associate, Boston Children's Hospital; Professor of Neurology, Harvard Medical School.

Research Focus

Early nervous system development, cell-cell communications.

Brief Research Description

Dr. He's group focuses on understanding the mechanism of Wnt signaling in vertebrate development and human diseases including cancer. They are interested in canonical Wnt/-catenin signaling and noncanonical Wnt signaling in anterior-posterior patterning, embryonic pluripotency, and CNS/brain development in Xenopus and mammals including mice and human, and in stem cell biology and disease modeling in mice and organoids. They aim to translate our understanding into therapeutic targeting of Wnt signaling for human disease/cancer treatment.

Key Publications (PMCIDs)

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Zhang XJ, Abreu JG, Yokota C, MacDonald BT, Singh S, Almeida-Coburn KL, Cheong S-M, Zhang MM, Ye Q-Z, Hang HC, Steen H, He X.
http://www.childrenshospital.org/research/researchers/h/xi-he

Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.
Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X.
Science. 2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389. Epub 2013 Apr 11. PMID: 23579495; PMCID: PMC3788643

Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.
Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X.
ev Cell. 2015 Mar 23;32(6):719-30. doi: 10.1016/j.devcel.2015.02.014. Epub 2015 Mar 12. PMID: 25771893; PMCID: PMC4375027

APC Deficiency Leads to β-Catenin Stabilization and Signaling Independent of LRP5/6.
Chen M, He X.
ev Cell. 2019 Jun 17;49(6):825-826. doi: 10.1016/j.devcel.2019.05.013. PMID: 31211990

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