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Scott Pomeroy, MD, PhD

Neurologist-in-Chief, Chairman, Dept of Neurology; Director, IDDRC; Bronson Crothers Professor of Neurology, Harvard Medical School.

Research Focus
Molecular and cellular biology of brain tumors.
Brief Research Description
The Pomeroy lab has shown that medulloblastomas, the most common malignant brain tumors in children, consist of multiple molecular subgroups each with unique gene expression and driver mutations (Cho et al., J Clin Oncol. 2011; Pugh et al. Nature 2012). A molecular classification based on these subgroups has been adopted by the WHO as the international standard. Recent work using integrative genomics, whole genome sequencing, proteomic and especially phosphoproteomic data has detected functional subtypes with driver signaling pathways that are not evident in the transcriptome (Archer et al. Cancer Cell 2018), identifying new targets for small molecule therapies.
Key Publications (PMCIDs)

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL.
J Clin Oncol. 2011 Apr 10;29(11):1424-30. doi: 10.1200/JCO.2010.28.5148. Epub 2010 Nov 22. PMID: 21098324; PMCID: PMC3082983

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ.
Nature. 2012 Aug 2;488(7409):106-10. doi: 10.1038/nature11329. PMID: 22820256; PMCID: PMC3413789

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Pierre-François J, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA, Mesirov JP, Pomeroy SL, Fraenkel E.
Cancer Cell. 2018 Sep 10;34(3):396-410.e8. doi: 10.1016/j.ccell.2018.08.004. PMID: 30205044; PMCID: PMC6372116

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