Rosalind Segal

Rosalind Segal, MD, PhD

Associate in Medicine, Boston Children’s Hospital; Chair, Pediatric Hematology/Oncology, Dana-Farber Cancer Institute; Professor of Neurobiology & Dean for Graduate Education, Harvard Medical School.

Research Focus

Axon biology: trafficking of signaling molecules and RNAs to regulate survival and function.

Brief Research Description

Dr. Segal's laboratory investigates the process of neural development – how the nervous system develops from neural stem cells to neurons that function within a neural circuit. They focus on the extracellular cues, such as growth factors and morphogens that direct this complex process. A major focus of the lab is to use this developmental view to identify and target pathways that cause the abnormal proliferation, migration and survival of brain tumors.

Key Publications (PMCIDs)

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.
Cosker KE, Fenstermacher SJ, Pazyra-Murphy MF, Elliott HL, Segal RA.
Nat Neurosci. 2016 May;19(5):690-696. doi: 10.1038/nn.4280. Epub 2016 Mar 28. PMID: 27019013; PMCID: PMC5505173

Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.
Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA.
Neuron. 2017 Oct 11;96(2):373-386.e6. doi: 10.1016/j.neuron.2017.09.034. PMID: 29024661; PMCID: PMC5680044

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