Rebekah Mannix

Rebekah Mannix, MD, MPH

Senior Associate Physician in Medicine, Division of Emergency Medicine, Boston Children’s Hospital; Associate Professor of Pediatrics and Emergency Medicine, Harvard Medical School.

Research Focus

Use of traumatic brain injury models to develop new biomarkers of injury and recovery.

Brief Research Description

Traumatic brain injury (TBI) is one of the most common causes of acquired intellectual or developmental disability in children. Even mild TBI can disrupt developmental trajectories for months to years. Dr. Mannix's research focuses on utilizing clinically relevant TBI models to develop new biomarkers of injury and recovery that can be used to evaluate objectively the efficacy of interventions both in the preclinical and clinical setting.

Key Publications (PMCIDs)

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.
Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, Bailes J, Meehan W, Zeidel M, Lu KP, Zhou XZ.
Nat Commun. 2017 Oct 17;8(1):1000. doi: 10.1038/s41467-017-01068-4. PMCID: PMC5645414

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats.
Robinson S, Winer JL, Chan LAS, Oppong AY, Yellowhair TR, Maxwell JR, Andrews N, Yang Y, Sillerud LO, Meehan WP 3rd, Mannix R, Brigman JL, Jantzie LL.
Front Neurol. 2018 Jun 19;9:451. doi: 10.3389/fneur.2018.00451. eCollection 2018. PMCID: PMC6018393

Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine.
Fischer KD, Houston ACW, Desai RI, Doyle MR, Bergman J, Mian M, Mannix R, Sulzer DL, Choi SJ, Mosharov EV, Hodgson NW, Bechtholt A, Miczek KA, Rosenberg PA.
Psychopharmacology (Berl). 2018 May;235(5):1371-1387. doi: 10.1007/s00213-018-4848-1. Epub 2018 Feb 22. PMCID: PMC5999338

Memantine Mitigates Oligodendrocyte Damage after Repetitive Mild Traumatic Brain Injury.
Ma G, Liu C, Hashim J, Conley G, Morriss N, Meehan WP, Qiu J, Mannix R.
Neuroscience. 2019 Nov 21;421:152-161. doi: 10.1016/j.neuroscience.2019.10.016. Epub 2019 Nov 1. PMID: 31682950

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