Paul Rosenberg

Paul Rosenberg, MD, PhD

Senior Associate, Department of Neurology, Boston Children's Hospital; Associate Professor of Neurology, Harvard Medical School.

Research Focus

Molecular Mechanisms of brain injury.

Brief Research Description

Dr. Rosenberg's lab is focused on understanding the causes of brain injury in premature infants. Periventricular leukomalacia (PVL) is the principal lesion underlying cerebral palsy in premature infants and is accompanied by widespread axonal injury. The primary cell-type injured in PVL is the developing oligodendrocyte. They are characterizing the mechanisms of cell death, the basis for the developmental regulation of the vulnerability to injury, and possible approaches for therapeutic intervention. They are also studying the mechanisms underlying axonal injury. In addition, they have launched a translational project using exosomes in blood to discover biomarkers of brain development and injury in premature infants.

Key Publications (PMCIDs)

Zinc homeostasis and zinc signaling in white matter development and injury.
Elitt CM, Fahrni CJ, Rosenberg PA.
Neurosci Lett. 2019 Aug 10;707:134247. doi: 10.1016/j.neulet.2019.05.001. Epub 2019 May 4. PMID: 31059767

Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1.
Laprairie RB, Petr GT, Sun Y, Fischer KD, Denovan-Wright EM, Rosenberg PA.
Neurochem Int 2019;123:85-94. PMCID: PMC6249114

Deletion of Neuronal GLT-1 in mice reveals Its role in synaptic glutamate homeostasis and mitochondrial function.
McNair LF, Andersen JV, Aldana BI, Hohnholt MC, Nissen JD, Sun Y, Fischer KD, Sonnewald U, Nyberg N, Webster SC, Kapur K, Rimmele TS, Barone I, Hawks-Mayer H, Lipton JO, Hodgson NW, Hensch TK, Aoki CJ, Rosenberg PA, Waagepetersen HS.
J Neurosci 2019;39(25):4847-63. PMCID: PMC6670249

Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.
Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert HY, Erdogan B, Asdourian MS, Shrock C, de Lima S, Apfel UP, Zhuo Y, Hershfinkel M, Lippard SJ, Rosenberg PA, Benowitz L.
Proc Natl Acad Sci U S A 2017;114(2):E209-E18. PMCID: PMC5240690

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