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The Kaeser Lab

Pascal Kaeser, MD

Associate Professor of Neurobiology, Harvard Medical School.

Research Focus
Mechanisms of neurotransmitter secretion.
Brief Research Description
Inaccurate regulation of signal transmission at neuronal synapses is a hallmark of many brain disorders. However, the molecular mechanisms that regulate signal transmission are poorly understood. Dr. Kaeser's lab dissects mechanisms of the protein machinery that controls the release of neurotransmitters. Understanding how these mechanisms operate will provide insights into mechanisms of brain development and neuronal plasticity, will help understanding neurodevelopmental disorders such as autism and intellectual disability, and will reveal novel insights into functions and dysfunctions of the nervous system.
Key Publications (PMCIDs)

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
WWang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS.
Neuron. 2016 Aug 17;91(4):777-791. doi: 10.1016/j.neuron.2016.07.005. PMID: 27537483; PMCID: PMC4991631

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS.
Cell. 2018 Feb 8;172(4):706-718.e15. doi: 10.1016/j.cell.2018.01.008. Epub 2018 Feb 1. PMID: 29398114; PMCID: PMC5807134

RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.
de Jong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS.
Neuron. 2018 Apr 18;98(2):335-349.e7. doi: 10.1016/j.neuron.2018.03.011. Epub 2018 Mar 29. PMID: 29606581; PMCID: PMC5910229

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