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Fagiolini Lab

Michela Fagiolini, PhD

Research Associate in Neurology, Boston Children's Hospital; Associate Professor of Neurology, Harvard Medical School.

Research Focus
Circuit dissection and translational biomarkers of neurodevelopment disorders.
Brief Research Description
Dr. Fagiolini’s research focuses in understanding the mechanisms underlying experience-dependent cortical circuit development and refinement during early postnatal life in health and neurodevelopmental disorders using a multidisciplinary approach. Her laboratory has discovered a clear visual phenotype in mouse models and patients with Rett Syndrome disorder, a leading cause of intellectual disability with autistic features, and developed new therapeutic interventions specifically targeting NMDA receptor now in clinical trials. Current effort is to develop new quantitative, noninvasive, and highly translational biomarkers for the early detection of developmental disorders using machine learning across species.
Key Publications (PMCIDs)

Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients.
Artoni P, Piffer A, Vinci V, LeBlanc J, Nelson CA, Hensch TK, Fagiolini M.
Proc Natl Acad Sci U S A. 2019 Jul 22:201820847. doi: 10.1073/pnas.1820847116. Epub ahead of print. PMID: 31332003

NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity.
Picard N, Takesian AE, Fagiolini M, Hensch TK.
Mol Psychiatry. 2019 Jun;24(6):828-838. doi: 10.1038/s41380-018-0341-9. Epub 2019 Jan 29. PMID: 30696941; PMCID: PMC6756203

MeCP2: an epigenetic regulator of critical periods.
Picard N, Fagiolini M.
Curr Opin Neurobiol. 2019 Dec;59:95-101. doi: 10.1016/j.conb.2019.04.004. Epub 2019 Jun 1. PMID: 31163286

Transparent arrays of bilayer-nanomesh microelectrodes for simultaneous electrophysiology and two-photon imaging in the brain.
Qiang Y, Artoni P, Seo KJ, Culaclii S, Hogan V, Zhao X, Zhong Y, Han X, Wang PM, Lo YK, Li Y, Patel HA, Huang Y, Sambangi A, Chu JSV, Liu W, Fagiolini M, Fang H.
Sci Adv. 2018 Sep 5;4(9):eaat0626. doi: 10.1126/sciadv.aat0626. PMID: 30191176; PMCID: PMC6124910

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