Michael Greenberg

Michael Greenberg, PhD

Nathan Marsh Pusey Professor of Neurobiology, Chair, Department of Neurobiology, Harvard Medical School.

Research Focus

Experience-dependent neural circuit development.

Brief Research Description

Dr. Greenberg's interactions with the outside world trigger changes at neuronal synapses that are critical for proper brain development and higher cognitive function. Research in the Greenberg laboratory has focused on the identification of a genetic program that is activated by neuronal activity, the mechanisms of signal transduction that carry the neuronal activity-dependent signal from the membrane to the nucleus, and the identification of regulators of this experience-dependent process that affect synapse development and plasticity. They are particularly interested in those activity-dependent processes whose dysfunction can lead to the development of diseases of cognitive function.

Key Publications (PMCIDs)

Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.
Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum DR, Kinde B, Gabel HW, Greenberg ME.
Cell 2017;171(5):1151-64 e16. PMCID: PMC5693680

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement
Cheadle L, Tzeng CP, Kalish BT, Harmin DA, Rivera S, Ling E, Nagy MA, Hrvatin S, Hu L, Stroud H, Burkly LC, Chen C, Greenberg ME.
Neuron 2018;99(3):525-39 e10. PMCID: PMC6101651

A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2.
Andzelm MM, Vanness D, Greenberg ME, Linden DJ.
Cell Rep 2019;26(5):1089-97 e3. PMCID: PMC6433166

ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation.
Sharma N, Pollina EA, Nagy MA, Yap EL, DiBiase FA, Hrvatin S, Hu L, Lin C, Greenberg ME.
Neuron. 2019 Apr 17;102(2):390-406.e9. doi: 10.1016/j.neuron.2019.02.007. PMCID: PMC6504996

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