Marcos Simoes-Costa

Marcos Simoes-Costa, PhD

Associate Professor, Department of Systems Biology and Department of Pathology at Harvard Medical School

Research Focus

How cellular diversity arises during vertebrate embryonic development

Brief Research Description

Multicellular organisms are formed by a large number of cell types, which serve as the components of tissues and organs. In the Simoes-Costa Lab, we study how cellular diversity arises during vertebrate embryonic development. We employ systems-level approaches to decode the molecular programs that drive changes in cell identity. Our research group is particularly interested in how gene regulatory networks operate in space to generate complex arrangements of cells.

Key Publications (PMCIDs)

Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells.
Hovland AS, Bhattacharya D, Azambuja AP, Pramio D, Copeland J, Rothstein M, Simoes-Costa M.
Dev Cell. 2022 Oct 10;57(19):2257-2272.e5; Epub 2022 Sep 30. PubMed PMID: 36182685; PubMed Central PMCID: PMC9743141.

Sociosexual behavior requires both activating and repressive roles of Tfap2e/ AP-2ε in vomeronasal sensory neurons
Lin JM, Mitchell TA, Rothstein M, Pehl A, Taroc EZM, Katreddi RR, Parra KE, Zuloaga DG, Simoes-Costa M, Forni PE
Elife. 2022 Sep 16;11. doi: 10.7554/eLife.77259. PubMed PMID: 36111787; PubMed Central PMCID: PMC9525060.

Micromanaging pattern formation: miRNA regulation of signaling systems in vertebrate development.
Copeland J, Wilson K, Simoes-Costa M
FEBS J. 2022 Sep;289(17):5166-5175. doi: 10.1111/febs.16139. Epub 2021 Aug 3. PubMed PMID: 34310060; PubMed Central PMCID: PMC10202149

< BACK TO DIRECTORY