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Lisa Prock, MD, MPH

Associate Chief, Division of Developmental Medicine, and Director, Developmental Medicine Center, Boston Children's Hospital; Assistant Professor in Pediatrics, Harvard Medical School.

Research Focus
Clinical trials in individuals with neurodevelopment disorders.
Brief Research Description
Dr. Prock’s primary research focuses on conducting clinical trials using both pharmacologic and behavioral interventions for individuals with a range of neurodevelopmental disorders including Fragile X. Dr. Prock is also the site PI for a multisite autism registry (SPARK) and a multisite NeuroNEXT trial for children with Fragile X Syndrome. This NeuroNEXT trial is the first effort in young children (ages 3 to 6 years) to conduct a double blind placebo-controlled using a combination of an MGluR5 NAM (AFQ056)and an intensive language learning intervention to examine a new paradigm for neural plasticity in individuals with Fragile X Syndrome.
Key Publications (PMCIDs)

SPARK: A US Cohort of 50,000 Families to Accelerate Autism Research.
SPARK Consortium. Electronic address: pfeliciano@simonsfoundation.org; SPARK Consortium
Neuron. 2018 Feb 7;97(3):488-493. doi: 10.1016/j.neuron.2018.01.015. PMID: 29420931.

NDD Exome Scoping Review Work Group. Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders.
Srivastava S, Love-Nichols JA, Dies KA, Ledbetter DH, Martin CL, Chung WK, Firth HV, Frazier T, Hansen RL, Prock L, Brunner H, Hoang N, Scherer SW, Sahin M, Miller DT
Genet Med. 2019 Nov;21(11):2413-2421. doi: 10.1038/s41436-019-0554-6. Epub 2019 Jun 11. PMID: 31182824; PMCID: PMC6831729.

The phenotypical implications of immune dysregulation in fragile X syndrome.
Yu KH, Palmer N, Fox K, Prock L, Mandl KD, Kohane IS, Prilutsky D.
Eur J Neurol. 2020 Mar;27(3):590-593. doi: 10.1111/ene.14146. Epub 2020 Jan 17. PMID: 31953887.

Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes.
Feliciano P, Zhou X, Astrovskaya I, Turner TN, Wang T, Brueggeman L, Barnard R, Hsieh A, Snyder LG, Muzny DM, Sabo A; SPARK Consortium, Gibbs RA, Eichler EE, O'Roak BJ, Michaelson JJ, Volfovsky N, Shen Y, Chung WK.
NPJ Genom Med. 2019 Aug 23;4:19. doi: 10.1038/s41525-019-0093-8. PMID: 31452935; PMCID: PMC6707204.

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