Judith Steen

Judith Steen, PhD

Associate in Neurology, Boston Children’s Hospital; Associate Professor in Neurology, Harvard Medical School.

Research Focus

Novel proteogenomics methods in studies of neurodevelopment, regeneration, and neurodegeneration.

Brief Research Description

The Steen laboratory uses proteogenomic methods to understand the role of genetically identified variants of disease proteins in neurodegeneration and developmental disorders. They focus on neurodevelopmental diseases such as Spinal Muscular Atrophy and Autism as well as neurodegenerative diseases involving proteopathies such as Tauopathies, Synucleinopathies and TDP43opathies. Using both analytical and computational methods developed in our laboratories, they identify novel therapeutic targets and study these targets using functional approaches.

Key Publications (PMCIDs)

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.
Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA.
Anal Chem 2016;88(7):3704-14. PMCID: PMC5808556

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.
Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.
Stem Cell Reports 2016;7(3):325-40. PMCID: PMC5032560

f-divergence cutoff index to simultaneously identify differential expression in the integrated transcriptome and proteome.
Tang S, Hemberg M, Cansizoglu E, Belin S, Kosik K, Kreiman G, Steen H, Steen J.
Nucleic Acids Res 2016;44(10):e97. PMCID: PMC4889934

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.
Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA.
Neuron. 2015 May 20;86(4):1000-1014. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30. PMID: 25937169; PMCID: PMC4551425

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