Jonathan Lipton

Jonathan Lipton, MD, PhD

Assistant Professor of Neurology, Harvard Medical School.

Research Focus

Circadian rhythms and sleep in neurological health and disease.

Brief Research Description

The overarching goal of Dr. Lipton's laboratory is to understand the interactions between the circadian timekeeping system and neurological disorders. They have several inter-related goals: (1) Define the mechanisms that underlie circadian rhythms at synapses. (2) Decode circadian protein synthesis in the brain. (3) Understand how the circadian timekeeper senses and adapts to cellular stress to promote homeostatic resilience.

Key Publications (PMCIDs)

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Behne R, Teinert J, Wimmer M, D'Amore A, Davies AK, Scarrott JM, Eberhardt K, Brechmann B, Chen IP, Buttermore ED, Barrett L, Dwyer S, Chen T, Hirst J, Wiesener A, Segal D, Martinuzzi A, Duarte ST, Bennett JT, Bourinaris T, Houlden H, Roubertie A, Santorelli FM, Robinson M, Azzouz M, Lipton JO, Borner GHH, Sahin M, Ebrahimi-Fakhari D.
Hum Mol Genet. 2020 Jan 15;29(2):320-334. doi: 10.1093/hmg/ddz310. PMID: 31915823; PMCID: PMC7001721

Mechanisms of sleep and circadian ontogeny through the lens of neurodevelopmental disorders.
Barone I, Hawks-Mayer H, Lipton JO.
Neurobiol Learn Mem. 2019 Apr;160:160-172. doi: 10.1016/j.nlm.2019.01.011. Epub 2019 Jan 19. PMID: 30668981

Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy.
Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Rep 2017;20(4):868-80. PMCID: PMC5603761
Cell Rep 2017;20(4):868-80. PMCID: PMC5603761

Neural Circuitry of Wakefulness and Sleep.
Scammell TE, Arrigoni E, Lipton JO.
Neuron 2017;93(4):747-65. PMCID: PMC5325713

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1- Mediated Phosphorylation.
Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M.
Cell. 2015;161(5):1138-51. PMCID: PMC4447213

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