Jeffrey Holt, PhD
Research Associate in Otolaryngology and Neurology, Boston Children's Hospital; Professor of Otolaryngology and of Neurology, Harvard Medical School.
Research Focus
Molecular basis of sensory signals in hearing and deafness.
Brief Research Description
Dr. Holt's lab aims to understand how the sensory cells and neurons in the normal inner ear function. He is attempting to identify the molecular components required for sensory function and identify why mutations in those molecules lead to dysfunction. His long term goal is to use this information to design and translate therapeutic strategies aimed at restoring sensory transduction and inner ear function.
Key Publications (PMCIDs)
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.
György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP.
Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. PMID: 31270503; PMCID: PMC6802276