Emanuela Gussoni, PhD
Assistant in Medicine, Boston Children's Hospital; Associate Professor of Pediatrics, Harvard Medical School.
Research Focus
Muscular dystrophies and downstream mechanisms resulting from primary losss of protein function.
Brief Research Description
Dr. Gussoni's work focuses on muscle stem cells and how their activity can slow the progression of muscular dystrophy. She studies CD82, a tetraspanin that binds proteins at the surface of muscle stem cells, thus regulating their activation and ability to repair damaged muscle. They know that loss of CD82 in dystrophic muscle leads to a more severe disease, suggesting its function in muscle fiber self-repair.
Key Publications (PMCIDs)
CD82 Is a Marker for Prospective Isolation of Human Muscle Satellite Cells and Is Linked to Muscular Dystrophies.
Alexander MS, Rozkalne A, Colletta A, Spinazzola JM, Johnson S, Rahimov F, Meng H, Lawlor MW, Estrella E, Kunkel LM, Gussoni E.
ell Stem Cell. 2016 Dec 1;19(6):800-807. doi: 10.1016/j.stem.2016.08.006. Epub 2016 Sep 15. PMID: 27641304; PMCID: PMC5135584
Isolation of Primary Human Skeletal Muscle Cells.
Spinazzola JM, Gussoni E.
Bio Protoc. 2017 Nov 5;7(21):e2591. doi: 10.21769/BioProtoc.2591. PMID: 29152538; PMCID: PMC5687092