Eliot Shearer

Eliot Shearer, MD, PhD

Assistant Professor of Otolaryngology Head and Neck Surgery

Research Focus

The genomics and molecular physiology of hearing loss

Brief Research Description

Dr. Shearer is the Principal Investigator of the Translational Hearing Genomics Lab. The lab works to improve our understanding of human hearing loss by unraveling the molecular physiology of hearing, identifying new hearing loss genes, advancing hearing loss diagnostics, and developing gene therapy for hearing loss. The lab also studies ways to improve newborn hearing screen tests using new technologies and ways to improve outcomes for children with cochlear implants. Human studies as well as mouse models are used to achieve these goals.

Key Publications (PMCIDs)

Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing
Shearer, A.E., DeLuca, A.P., Hildebrand, M.S., Taylor, K.R., Gurrola, J., Scherer, S., Scheetz, T.E. and Smith, R.J., 2010.
Proceedings of the National Academy of Sciences. 2010.,107(49), pp.21104-21109

Utilizing ethnic-specific differences in minor allele frequency to recategorize reported pathogenic deafness variants.
Shearer, A.E., Eppsteiner, R.W., Booth, K.T., Ephraim, S.S., Gurrola II, J., Simpson, A., Black-Ziegelbein, E.A., Joshi, S., Ravi, H., Giuffre, A.C. and Happe, S.,
The American Journal of Human Genetics. 2010, 95(4), pp.445-453.

A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children.
Shearer, A.E., Shen, J., Amr, S., Morton, C.C. and Smith, R.J.
Genetics in Medicine. 2019, 21(11), pp.2614-2630.

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.
Shubina-Oleinik, O., Nist-Lund, C., French, C., Rockowitz, S., Shearer, A.E. and Holt, J.R.
Science Advances, 2021, 7(51), p.eabi7629

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