David Glahn, PhD

Associate Chief for Research, Department of Psychiatry; Director, Tommy Fuss Center for Neuropsychiatric Disease Research; Director, Early Psychosis Investigation Center (EPICenter); Director, Neuropsychiatric Genetics Program (NGP); Endowed chair in Behavioral Science Research, Boston Children’s Hospital; Professor of Psychology in the Department of Psychiatry, Harvard Medical School.

Research Focus
Psychiatric and imaging genetics.
Brief Research Description
The primary aims of Dr. Glahn's research program are to (i) elucidate the biological antecedents of psychotic and affective disorders through the integration of clinical, cognitive, neuroimaging, peripheral blood markers and molecular genetic information, and to (ii) determine the impact of genetic and environmental variation on normative brain structure and function and its development. Given that psychiatric and cognitive/imaging antecedents of psychosis or affective dysregulation appear in childhood and adolescence, typically years before the formal onset of the illness, a major component of my research focuses on genetic and environmental aspects of individual differences across development. Dr. Glahn is the inaugural director of the Tommy Fuss Center for Developmental Neuropsychiatric Disease Research at Boston Children’s Hospital, where he also serves as the Associate Chair for Research in Department of Psychiatry. He is the director of the Early Psychosis Investigation Center (EPICenter) direct the Neuropsychiatric Genetics Program (NPG). At Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, he directs the Affective Disorders and Psychosis (ADAPTING) laboratory.
Key Publications (PMCIDs)

Genetic control over the resting brain.
Glahn DC, Winkler AM, Kochunov P, Almasy L, Duggirala R, Carless MA, Curran JC, Olvera RL, Laird AR, Smith SM, Beckmann CF, Fox PT, Blangero J.
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1223-8. doi: 10.1073/pnas.0909969107. PMID: 20133824; PMCID: PMC2824276

Rediscovering the value of families for psychiatric genetics research.
Glahn DC, Nimgaonkar VL, Raventós H, Contreras J, McIntosh AM, Thomson PA, Jablensky A, McCarthy NS, Charlesworth JC, Blackburn NB, Peralta JM, Knowles EEM, Mathias SR, Ament SA, McMahon FJ, Gur RC, Bucan M, Curran JE, Almasy L, Gur RE, Blangero J.
Mol Psychiatry. 2019 Apr;24(4):523-535. doi: 10.1038/s41380-018-0073-x. Epub 2018 Jun 28. PMID: 29955165; PMCID: PMC7028329

High dimensional endophenotype ranking in the search for major depression risk genes.
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW Jr, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J.
Biol Psychiatry. 2012 Jan 1;71(1):6-14. doi: 10.1016/j.biopsych.2011.08.022. Epub 2011 Oct 7. PMID: 21982424; PMCID: PMC3230692