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David Ginty, PhD

Investigator, Howard Hughes Medical Institute; Associate Director of the Harvard Program in Neuroscience; Edward R. and Anne G. Lefler Professor of Neurobiology, Harvard Medical School.

Research Focus
Somatosensation in health and disease.
Brief Research Description
The sense of touch is key to our experience of the world around us. Research in the Ginty laboratory uses the mouse as a model system to address the development, organization, and function of mechanosensory neurons and the neural circuits that underlie the perception of touch and pain, in health and disease.
Key Publications (PMCIDs)

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.
Cell. 2019 Aug 8;178(4):867-886.e24. doi: 10.1016/j.cell.2019.07.024. PMID: 31398341; PMCID: PMC6704376

Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking.
Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell. 2015 Dec 17;163(7):1783-1795. doi: 10.1016/j.cell.2015.11.060. PMID: 26687362;
Cell. 2015 Dec 17;163(7):1783-1795. doi: 10.1016/j.cell.2015.11.060. PMID: 26687362; PMCID: PMC4890169

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
Cell. 2017 Jan 12;168(1-2):295-310.e19. doi: 10.1016/j.cell.2016.12.010. Epub 2016 Dec 29. PMID: 28041852; PMCID: PMC5236062

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