Cellular and Circuit Mechanisms of Attention in Health and Disease

Certain basic cognitive processes are central to navigating the world around us. Attention, for example is important for almost all of our conscious actions, yet there's so much we still don't know about the cell types and circuits that support it. In our lab, we work to discover and characterize biomarkers of successful and dysfunctional attention and cognition by monitoring and manipulating relevant circuits using Calcium imaging, optogenetics, pharmacogenetics, various slice and in vivo electrophysiology approaches, and behavior. We'll examine these biomarkers in mice with mutations linked to autism-spectrum disorders, schizophrenia, and epilepsy to highlight shared signatures of cognitive dysfunction. We are particularly interested in the role of interneurons in regulating neuronal ensembles critical for completing various cognitive tasks. A long-term goal is to identify therapeutic targets for treating patient populations across disease contexts with treatment-resistant cognitive impairments.