Non-canonical olfactory and vomeronasal receptors

Olfaction is a valuable model system to study general functions of the human brain that are not well understood, including perception and behavior.  Furthermore, neural circuit dysfunction underlies a range of intellectual and emotional disorders, so principles that emerge from studying sensory circuit function will potentially have a broad impact on human health. Olfactory neural circuits generate tens of thousands of distinct perceptions and influence innate behaviors.  Mammals have two principal olfactory tissues: the main olfactory epithelium and the vomeronasal organ, each of which contains large families of dedicated sensory receptors and activates distinct neuronal circuits.  We recently identified two non-canonical families of mammalian chemosensory receptors- trace amine-associated receptors and formyl peptide receptors- that are distinct from previously described odorant and vomeronasal receptors.  In this proposal, we aim to understand the evolution, cellular organization, and chemoreceptive fields of these novel sensory receptors, to provide additional insight into the molecular mechanisms that underlie olfaction in mammals.