C6ORF32, an HDAC6-binding protein that regulates myoblast differentiation

This project will dissect the regulatory connection between HDAC6 and C6ORF32, and how this connection affects myogenic differentiation. This goal will be achieved through in vitro and in vivostudies. The proposed work will open the possibility of modulating the HDAC6-C6ORF32 regulatoryinteraction to enhance muscle cell fusion, with the broader scope of using C6ORF32 as a new target formuscle repair.