Return to list Yang Shi, PhD

Investigator

Yang Shi, PhD

Title

Professor of Cell Biology; Professor of Pediatrics, Harvard Medical School
Merton Bernfield Professor of Neonatology, Boston Children’s Hospital

Department

Newborn Medicine

Address

Boston Children's Hospital
Division of Newborn Medicine
300 Longwood Avenue, BCH3146
Boston, MA 02115

Phone

617-919-3100

Email

yang.shi@childrens.harvard.edu

URL

http://www.childrenshospital.org/research-and-innovation/research/researchers/s/yang-shi

Biography

My laboratory has a longstanding interest in transcription and chromatin regulation. We identified LSD1 as the first histone demethylase in 2004 and numerous HmjC domain-containing demethylases subsequently, thus revealing the dynamic nature of histone methylation regulation, a modification that was long considered irreversible. We continue to be interested in understanding the molecular mechanism by which LSD1 and other histone demethylases play in regulation chromatin and epigenetic states of the cell and their roles in development and disseases.

Research
R01 MH096066