Return to list Thomas Scammell, M.D.
Thomas Scammell, M.D.
Professor of Neurology, Harvard Medical School
Physician, Associate Professor, Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA 02215
Dr. Scammell is a clinician-scientist with an interest in narcolepsy and other sleep disorders. His lab consists of 6-8 postdoctoral fellows and graduate students, and he also provides clinical care to patients with sleep disorders. Research in the Scammell Lab focuses on the neurobiology of sleep and the neural basis of narcolepsy. Many of the current projects use anatomical, physiological, and molecular techniques in mice to identify the neural mechanisms through which loss of the orexin neuropeptides gives rise to the sleepiness and cataplexy of narcolepsy. Other ongoing projects examine wake promoting cholinergic neurons of the pons and basal forebrain, the interaction of sleep and pain, and the wake-promoting role of histamine-producing neurons. Some studies use post-mortem human brain tissue to examine narcolepsy and the effects of traumatic brain injury on wake-promoting systems. Techniques used in the lab include optogenetics, DREADDs, sleep recordings in mice, cre-dependent pathway tracing, immunostaining, in situ hybridization, and production of novel recombinant mice.
- R01 DE022912