Return to list Min Dong, PhD

Investigator

Min Dong, PhD

Title
Assistant Professor of Microbiology and Immunobiology, Harvard Medical School
Department

Microbiology and Immunobiology

Address

Boston Children's Hospital
300 Longwood Avenue
Boston, MA 02115

Phone

857-218-4232

Email

Min.Dong@childrens.harvard.edu

URL

http://donglab.hms.harvard.edu/

Biography

I was trained as a neuroscientist, obtained Ph.D. in neuroscience from the Neuroscience Training Program at the University of Wisconsin Madison and finished my postdoctoral studies in Dr. Edwin Chapman’s lab, a renowned HHMI investigator working on membrane trafficking, membrane fusion, and synaptic transmission. I was recently recruited to Boston Children’s Hospital in the main campus of Harvard Medical School as an endowed Assistant Professor. I hold joint faculty appointment at the Dept. of Urology at Boston Children’s Hospital and Dept. of Microbiology and Immunobiology at Harvard Medical School. I am also a faculty member in both Program in Neuroscience and Program in Biophysics graduate programs at Harvard University.

A major focus of my lab is in the field of cellular neuroscience, particularly on synaptic vesicle recycling and endosomal sorting. Neurons are highly specialized cells with sophisticated membrane trafficking processes. Our overarching goal is to understand how the membrane trafficking system is specialized and regulated in neurons and how defects in membrane trafficking pathways lead to neurodegeneration and other developmental diseases. Studying how pathogens exploit membrane trafficking systems in cells has been proven to be a powerful approach to understand the molecular mechanism of these critical cellular processes. Our current approach utilizes botulinum neurotoxins (BoNTs) and related tetanus neurotoxin (TeNT) as probes to investigate the critical membrane trafficking events in neurons.

Research
Long-term effects of botulinum neurotoxins on neuronal viability - R01 NS080833