Return to list Michela Fagiolini, PhD

Investigator

Michela Fagiolini, PhD

Title

Assistant Professor of Neurology, Harvard Medical School
Research Associate in Neurology, Boston Children’s Hospital

Department

Neurology

Address

Boston Children's Hospital
F.M. Kirby Neurobiology Center
Center for Life Science, Room 13-034
3 Blackfan Circle
Boston, MA 2115

Phone

617-919-2419

Email

michela.fagiolini@childrens.harvard.edu

URL

http://dms.hms.harvard.edu/neuroscience/fac/Fagiolini.php

Biography

Neurons acquire multiple functional properties through experience-dependent development during specific times in early postnatal life called “critical periods”. In recent years they have achieved the first direct control over critical period timing by manipulating a specific subset of local inhibitory circuits in the visual cortex. Dr. Fagiolini's research focuses on the mechanisms underlying these fundamental processes and how they may be altered in neurodevelopmental disorders. To this end, they combine molecular techniques with electrophysiological and behavioral analysis of systems level phenomena in vivo.

Currently Dr. Fagiolini's lab is studying experience-dependent brain development in mouse models of autism spectrum disorders (ASDs). They are particularly focused on Rett syndrome, a leading cause of intellectual disability with autistic features. The lab is developing new strategies to restore cortical function and critical period timing by targeting Excitatory/Inhibitory circuits as a possible therapeutic intervention.

Research

1R01 NS095959-01A1