Return to list Mel B. Feany, MD, PhD

Investigator

Mel B. Feany, MD, PhD

Title

Professor of Pathology, Harvard Medical School

Department

Pathology

Address

Harvard Medical School
Harvard New Research Building, Room 630
77 Avenue Louis Pasteur
Boston, MA 02115

Phone

617-525-4405

Email

mel_feany@hms.harvard.edu

URL

http://feany-lab.bwh.harvard.edu/

Biography

The longstanding goal of the research in Dr. Feany's laboratory has been to understand the molecular and biochemical pathways leading to neuronal dysfunction and death in neurodegenerative disorders, including both common adult disorders, as well as rarer childhood neurodegenerative disorders. To that end,they have created models relevant to Alzheimer’s disease, Parkinson’s disease, neuronal ceroid lipofuscinosis, Alexander’s disease, and related disorders in the genetically tractable organism Drosophila. They have subsequent carried out large-scale forward genetic screens and microarray analyses in our models and have identified pathways, including excessive stabilization of the actin cytoskeleton, mitochondrial dysfunction, oxidative stress, lysosomal dysfunction, and cell cycle activation that mediate neurotoxicity in our fly models. The lab and others have demonstrated that many of these pathways also appear to contribute to neuropathology in mammalian models and in human disease.

Research
5P01 HD076892