Return to list Lois Smith, MD, PhD

Investigator

Lois Smith, MD, PhD

Title

Professor of Ophthalmology, Harvard Medical School
Associate in Ophthalmology, Boston Children’s Hospital

Department

Ophthalmology

Address

Boston Children's Hospital
Ophthalmology
300 Longwood Avenue
Boston, MA 02115

Phone

617-355-6414

Email

Lois.Smith@childrens.harvard.edu

URL

http://www.childrenshospital.org/directory/researchers/s/lois-smith

Biography

Dr. Smith is a pediatric ophthalmologist (clinician scientist) interested in basic mechanisms of retinopathy and in translational research. The lab is interested in ways to prevent vessel loss or ways to revascularize hypoxic retina to prevent loss of neural retina in ROP, AMD and in diabetes. Their basic work on the role of VEGF in retinopathy, IGF-1 in ROP, and omega 3 fatty acids as a way to prevent retinopathy have been translated into clinical practice, clinical trials and an algorithm to predict which infants will develop ROP. New avenues of research include modulation of the erythropoietin and Wnt pathway, Sirt-1, Semaphorin 3A and SOCS3 to modulate vascular and neuronal growth and survival.

Research
R01 EY01701
Lowy Medical Research Institute