Return to list Hans Christian Reinecker, MD

Investigator

Hans Christian Reinecker, MD

Title
Associate Professor of Medicine, Harvard Medical School
Department

Medicine

Address

Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114

Phone

617-724-2172

Email

hreinecker@partners.org

Biography

Dr. Reinecker is the Director of the Genetic Animal Models Core of the Center for the Study of Inflammatory Bowel Diseases (CSIBD) at Massachusetts General Hospital. He also is an Associate Professor of Medicine at Harvard Medical School and an Associate Immunologist at MGH. The Reinecker laboratory is focused on studying mucosal immunity to understand the basic rules that govern host control of the gut commensal and pathogenic microbiota. Dr. Reinecker has expertise in the generation of model systems to study the functional role of newly discovered central components of microbial pattern recognition that provide pivotal insights into the mechanisms that disrupt the control of mucosal immune responses. Dr. Reinecker has made seminal contributions, uncovering cellular and molecular mechanisms of microbial recognition and anti-microbial host defenses in the intestine. These include initial observations that established dendritic cells as a major microbial recognition and defense system in the intestine published in Science and the recent discovery of a cellular circuitry, whereby mucosal dendritic cells interact with the fenestrated capillary vessel system of the small intestine for the sampling of antigens in the blood circulation published in Immunity. Dr. Reinecker also made pioneering contributions to 3D in vivo imaging approaches of the immune system. Recently, the Reinecker uncovered that the ARHGEF2 deficient mice that were created in his lab phenocopies brain abnormalities found in members of a family with a homozygous premature stop codon in the human ARHGEF2. Specifically, the cranial MRIs revealed microencephaly, elongated midbrain, hypoplasia of the pons, ventral and dorsal longitudinal clefts (grooves) in pons and medulla, and inferior vermis hypoplasia. Male patients have a disturbance of fine motor movements and moderate intellectual disability and a severe developmental speech delay.

Research
Role of ARHGEF2 in brain development/Innate immune defense mechanisms in the intestine - R01 AI113333