Return to list Annapurna Poduri, M.D., MPH


Annapurna Poduri, M.D., MPH


Associate Professor of Neurology, Harvard Medical School
Assistant in Neurology, Boston Children’s Hospital




Boston Children's Hospital
300 Longwood Avenue
Boston, MA 02115






I am a clinician-scientist focused on understanding the genetic causes of human epilepsy with a long-term goal of creating models of human epilepsy and developing novel therapies. I serve on the faculty of Boston Children’s Hospital Department of Neurology and direct the Department’s Programs in Neurogenetics and Epilepsy Genetics. It was through my rich clinical training that I developed research hypotheses that I pursued in the laboratory of Christopher A. Walsh. My research spans a genetic spectrum from inherited to de novo genetic epilepsy, including epilepsy due to de novo somatic mutations in brain malformations.

I have recently joined the faculty of the F.M. Kirby Center for Neurobiology in the Department of Neurology at Boston Children’s Hospital and Harvard Medical School as a Principal Investigator. The overarching goal of my laboratory is the identification of targetable mechanisms that focus on the link between biological timing and brain disorders. We have three inter-related goals: (1) To determine the role of BMAL1 and the circadian clock in synaptic function and behavior. (2) To establish the biochemical and molecular mechanisms of BMAL1 and clock-mediated translation. (3) Determination of the molecular and developmental logic of the clock-dependent circadian translatome.


Identification and Molecular Characterization of Somatic Mutations in Malformations of Cortical Development - R01 NS094596
Zebrafish Models of PCDH19-Related Pediatric Epilepsy - Charles H. Hood Foundation Child Health Scholar Award