Retrograde Transport by Nerve Cells

The important observation of neuronal retrograde transport of horseradish peroxidase in the central nervous system by the LaVails in 1972 had a profound impact on neuroanatomy and neurobiology in the decades following the description of this phenomenon  (Science, 1972). This fundamental observation has had widespread use as a tool to establish anatomically interconnected areas of brain, and provided the seminal insight that nerve cell processes can sample the chemical environment and transport materials great distances back to the cell body.  Current IDDRC research that emanates from this historical work have identified signal transduction mechanisms that involve the rapid transport of ligand receptor complexes from nerve endings to the cell body, as demonstrated in the studies of Chen, Greenberg, Pomeroy, Segal, and Stiles.